ZEB1 抗体 (AA 391-739)
Quick Overview for ZEB1 抗体 (AA 391-739) (ABIN7120942)
抗原
See all ZEB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 391-739
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原理
- ZEB1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 391-739aa
Immunogen: zinc finger E-box binding homeobox 1
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亚型
- IgG
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应用备注
- WB: 1:500-1:5000, IP: 1:200-1:2000,IHC: 1:500-1:5000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))
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别名
- ZEB1
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背景
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Synonyms: Zinc finger E-box-binding homeobox 1|NIL-2-A zinc finger protein|Negative regulator of IL2|Transcription factor 8 (TCF-8)|ZEB1|AREB6|TCF8
Background: Acts as a transcriptional repressor. Inhibits interleukin-2(IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition(EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box(5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. The calculated molecular weight of ZEB1 is 124 kDa, but the post phosphorylation of protein is about 190-210 kDa. This is a rabbit polyclonal antibody raised against part of the full length of ZEB1 of human.
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分子量
- 210 kDa
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基因ID
- 6935
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UniProt
- P37275
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途径
- Regulation of Muscle Cell Differentiation
抗原
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