YY1 抗体
Quick Overview for YY1 抗体 (ABIN7120908)
抗原
See all YY1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- YY1 transcription factor
-
亚型
- IgG
-
-
anti-YY1 Transcription Factor (YY1) (AA 221-320) antibody
YY1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4A5 unconjugated
anti-YY1 Transcription Factor (YY1) antibodyYY1 适用: 人 WB, IP, IF, ChIP 宿主: 兔 Monoclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 1-414) antibodyYY1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) antibodyYY1 适用: 人, 大鼠, 斑马鱼, Cynomolgus WB, IHC (p) 宿主: 小鼠 Monoclonal 1183CT6-5-23-6 unconjugated
anti-YY1 Transcription Factor (YY1) (full length) antibodyYY1 适用: 人, 小鼠, 大鼠, Pig WB, IF 宿主: 小鸡 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 221-321) antibodyYY1 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C4 unconjugated
anti-YY1 Transcription Factor (YY1) (AA 1-414) antibodyYY1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 274-323) antibodyYY1 适用: 人, 小鼠, 大鼠, 犬, Cow, 绵羊, Pig, 小鸡, 猴, 马, 兔, 非洲爪蟾, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 1-200) antibodyYY1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 74-104), (N-Term) antibodyYY1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB2943 unconjugated
-
-
应用备注
- WB: 1:500-1:2000, IHC: 1:50-1:500
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
-
有效期
- 12 months
-
-
- YY1 (YY1 Transcription Factor (YY1))
-
别名
- YY1
-
背景
- Synonyms:DELTA, Delta transcription factor, INO80 complex subunit S, INO80S, NF E1, UCRBP, Yin and yang 1, YIN YANG 1, YY 1, YY1, YY1 transcription factor Background:Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3', some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein(BMP)-mediated cardiac-specific gene expression(PubMed:15329343). Binds to SMAD binding elements(SBEs)(5'-GTCT/AGAC-3') within BMP response element(BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures(Holliday junctions). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair, proposed to target the INO80 complex to YY1-responsive elements.
-
分子量
- 60 kDa, 75 kDa
-
基因ID
- 7528
-
UniProt
- P25490
抗原
-
