VPS41 抗体
Quick Overview for VPS41 抗体 (ABIN7120712)
抗原
See all VPS41 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- VPS41 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- vacuolar protein sorting 41 homolog
-
亚型
- IgG
-
-
anti-Vacuolar Protein Sorting 41 Homolog (VPS41) antibody
VPS41 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vacuolar Protein Sorting 41 Homolog (VPS41) (AA 755-853) antibodyVPS41 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Vacuolar Protein Sorting 41 Homolog (VPS41) (Internal Region) antibodyVerified VPS41 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Vacuolar Protein Sorting 41 Homolog (VPS41) (AA 467-516) antibodyVPS41 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Vacuolar Protein Sorting 41 Homolog (VPS41) (N-Term) antibodyVPS41 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Vacuolar Protein Sorting 41 Homolog (VPS41) (Middle Region) antibodyVPS41 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB: 1:200-1:1000, IF: 1:10-1:100
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- VPS41 (Vacuolar Protein Sorting 41 Homolog (VPS41))
-
别名
- VPS41
-
背景
-
Synonyms: Vacuolar protein sorting-associated protein 41 homolog|S53|VPS41
Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes(PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo(PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes(PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion(PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS(PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex(By similarity). May play a role in HOPS-independent function in the regulated secretory pathway(PubMed:24210660).
-
分子量
- 70 kDa, 93 kDa
-
基因ID
- 27072
-
UniProt
- P49754
抗原
-
