USP5 抗体 (AA 4-165)
Quick Overview for USP5 抗体 (AA 4-165) (ABIN7120527)
抗原
See all USP5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 4-165
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原理
- USP5 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 4-165aa
Immunogen: ubiquitin specific peptidase 5(isopeptidase T)
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亚型
- IgG
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应用备注
- WB: 1:500-1:5000, IP: 1:500-1:5000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- USP5 (Ubiquitin Specific Peptidase 5 (USP5))
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别名
- USP5
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背景
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Synonyms: Ubiquitin carboxyl-terminal hydrolase 5|Deubiquitinating enzyme 5|Isopeptidase T|Ubiquitin thioesterase 5|Ubiquitin-specific-processing protease 5|USP5|ISOT
Background: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
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分子量
- 93 kDa
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基因ID
- 8078
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UniProt
- P45974
抗原
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