USP15 抗体
Quick Overview for USP15 抗体 (ABIN7120499)
抗原
See all USP15 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- USP15 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ubiquitin specific peptidase 15
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 15 (USP15) (AA 1-235) antibody
USP15 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C10 unconjugated
anti-Ubiquitin Specific Peptidase 15 (USP15) (C-Term) antibodyKO Validated USP15 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 15 (USP15) (AA 151-180), (N-Term) antibodyUSP15 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB4337 unconjugated
anti-Ubiquitin Specific Peptidase 15 (USP15) (AA 852-952) antibodyUSP15 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 15 (USP15) (C-Term) antibodyUSP15 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 15 (USP15) (N-Term) antibodyUSP15 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 15 (USP15) (AA 1-260) antibodyUSP15 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 15 (USP15) (N-Term) antibodyUSP15 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 15 (USP15) (AA 691-740) antibodyUSP15 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 非洲爪蟾, 豚鼠, 猴, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:5000, IP: 1:500-1:5000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- USP15 (Ubiquitin Specific Peptidase 15 (USP15))
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别名
- USP15
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背景
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Synonyms: Ubiquitin carboxyl-terminal hydrolase 15|Deubiquitinating enzyme 15|Ubiquitin thioesterase 15|Ubiquitin-specific-processing protease 15|Unph-2|Unph4|USP15|KIAA0529
Background: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs(SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes(PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal(PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B(PubMed:24526689). Acts as an associated component of COP9 signalosome complex(CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
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分子量
- 112 kDa
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基因ID
- 9958
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UniProt
- Q9Y4E8
抗原
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