TDP1 抗体
Quick Overview for TDP1 抗体 (ABIN7120443)
抗原
See all TDP1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- TDP1 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- tyrosyl-DNA phosphodiesterase 1
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
-
别名
- TDP1
-
背景
-
Synonyms: Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1)|TDP1
Background: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
-
分子量
- 68 kDa
-
基因ID
- 55775
-
UniProt
- Q9NUW8
抗原
-