Synonyms:ACS3, bHLHa38, BPES2, BPES3, H twist, SCS, TWIST, twist homolog 1(Drosophila), Twist related protein 1, TWIST1 Background:TWIST1, a basic helix-loop-helix protein which acts as a transcriptional regulator, plays a central role in differentiation of mesodermal during embryogenesis. It is also implicated in tumorigenesis, invasion and metastasis. TWIST1 forms both homodimers(45KD) and heterodimers with E2A E proteins, and dimer partner selection is a critical mediator of TWIST function.(PMID:14724576, 16502419).