TWEAK 抗体
Quick Overview for TWEAK 抗体 (ABIN7120388)
抗原
See all TWEAK (TNFSF12) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TNFSF12 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- tumor necrosis factor (ligand) superfamily, member 12
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亚型
- IgG
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应用备注
- WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
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别名
- TNFSF12
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背景
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Synonyms: Tumor necrosis factor ligand superfamily member 12|APO3 ligand|TNF-related weak inducer of apoptosis (TWEAK)|Tumor necrosis factor ligand superfamily member 12, membrane form|Tumor necrosis factor ligand superfamily member 12, secreted form|TNFSF12|APO3L|DR3LG
Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene, such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
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分子量
- 25 kDa
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基因ID
- 8742
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UniProt
- O43508
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途径
- Apoptosis
抗原
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