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TFG 抗体

TFG 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7120305
发货至: 中国
  • 抗原 See all TFG 抗体
    TFG (Trk-Fused Gene (TFG))
    适用
    人, 小鼠, 大鼠
    宿主
    • 44
    • 7
    克隆类型
    • 37
    • 14
    多克隆
    标记
    • 24
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TFG antibody is un-conjugated
    应用范围
    • 43
    • 26
    • 8
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    TRK-fused gene
    亚型
    IgG
    Top Product
    Discover our top product TFG Primary Antibody
  • 应用备注
    WB: 1:500-1:5000, IHC: 1:20-1:200, IF: 1:50-1:500
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    TFG (Trk-Fused Gene (TFG))
    别名
    TRK fused gene (TFG 产品)
    别名
    wu:fb11c10 antibody, zgc:55342 antibody, zgc:77230 antibody, HMSNP antibody, SPG57 antibody, TF6 antibody, TRKT3 antibody, AI173908 antibody, trk-fused gene antibody, TRK-fused gene antibody, Trk-fused gene antibody, tfg antibody, TFG antibody, Tfg antibody
    背景
    Synonyms:FLJ36137, Protein TFG, TF6, TFG, TRK fused gene, TRK fused gene protein, TRKT3 Background:Protein TFG(TRK-fused gene protein) plays a role in regulating phosphotyrosine-specific phosphatase-1 activity. Mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma. Defects in TFG are a cause of thyroid papillary carcinoma(TPC), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Hereditary motor and sensory neuropathy with proximal dominant involvement(HMSN-P) is an autosomal-dominant neurodegenerative disorder characterized by widespread fasciculations, proximal-predominant muscle weakness, and atrophy followed by distal sensory involvement. Recent genetic investigation indicates that formation of TFG-containing cytoplasmic inclusions and concomitant mislocalization of TAR DNA-binding protein 43 kDa(TDP-43) underlie motor neuron degeneration in HMSN-P. Pathological overlap of proteinopathies involving TFG and TDP-43 highlights a new pathway leading to motor neuron degeneration.
    分子量
    50-55 kDa
    UniProt
    Q92734
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