TPX2 抗体 (AA 1-256)
Quick Overview for TPX2 抗体 (AA 1-256) (ABIN7120029)
抗原
See all TPX2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-256
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原理
- TPX2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 1-256aa
Immunogen: TPX2, microtubule-associated, homolog(Xenopus laevis)
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))
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别名
- TPX2
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背景
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Synonyms: Targeting protein for Xklp2|Differentially expressed in cancerous and non-cancerous lung cells 2 (DIL-2)|Hepatocellular carcinoma-associated antigen 519|Hepatocellular carcinoma-associated antigen 90|Protein fls353|Restricted expression proliferation-associated protein 100 (p100)|TPX2|C20orf1|C20orf2|DIL2|HCA519
Background: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules(PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation(PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha(PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation(PubMed:26165940).
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分子量
- 100 kDa
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基因ID
- 22974
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UniProt
- Q9ULW0
抗原
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