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TPX2 抗体 (AA 1-256)

This anti-TPX2 antibody is a 兔 多克隆 antibody detecting TPX2 in WB, ELISA, IP 和 IF. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7120029
发货至: 中国

Quick Overview for TPX2 抗体 (AA 1-256) (ABIN7120029)

抗原

See all TPX2 抗体
TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This TPX2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)
  • 抗原表位

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    AA 1-256

    原理

    TPX2 antibody

    纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    Immunogen sequence: 1-256aa

    Immunogen: TPX2, microtubule-associated, homolog(Xenopus laevis)

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

    别名

    TPX2

    背景

    Synonyms: Targeting protein for Xklp2|Differentially expressed in cancerous and non-cancerous lung cells 2 (DIL-2)|Hepatocellular carcinoma-associated antigen 519|Hepatocellular carcinoma-associated antigen 90|Protein fls353|Restricted expression proliferation-associated protein 100 (p100)|TPX2|C20orf1|C20orf2|DIL2|HCA519

    Background: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules(PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation(PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha(PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation(PubMed:26165940).

    分子量

    100 kDa

    基因ID

    22974

    UniProt

    Q9ULW0
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