SUV39H1 抗体
Quick Overview for SUV39H1 抗体 (ABIN7119616)
抗原
See all SUV39H1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SUV39H1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- suppressor of variegation 3-9 homolog 1(Drosophila)
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亚型
- IgG
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anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) antibody
SUV39H1 适用: 人, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (AA 179-412) antibodySUV39H1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (C-Term) antibodySUV39H1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (C-Term) antibodySUV39H1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 斑马鱼, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (AA 1-220) antibodySUV39H1 适用: 人 WB, IHC, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (C-Term) antibodySUV39H1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (AA 108-157) antibodySUV39H1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibodySUV39H1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB2153 unconjugated
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibodySUV39H1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term) antibodySUV39H1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))
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别名
- SUV39H1
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背景
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Synonyms: Histone-lysine N-methyltransferase SUV39H1|Histone H3-K9 methyltransferase 1 (H3-K9-HMTase 1)|Lysine N-methyltransferase 1A|Position-effect variegation 3-9 homolog|Suppressor of variegation 3-9 homolog 1 (Su(var)3-9 homolog 1)|SUV39H1|KMT1A|SUV39H
Background: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1(in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1(CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC(energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9'(H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
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分子量
- 48-50 kDa
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基因ID
- 6839
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UniProt
- O43463
抗原
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