Spt6 抗体
Quick Overview for Spt6 抗体 (ABIN7119612)
抗原
See all Spt6 (SUPT6H) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- suppressor of Ty 6 homolog(S. cerevisiae)
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亚型
- IgG
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anti-Suppressor of Ty 6 Homolog (SUPT6H) (AA 1500-1726) antibody
SUPT6H 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 6 Homolog (SUPT6H) (N-Term) antibodySUPT6H 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, 斑马鱼, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 6 Homolog (SUPT6H) antibodySUPT6H 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 6 Homolog (SUPT6H) (N-Term) antibodySUPT6H 适用: 人, 犬, Cow, 马, 兔, 豚鼠, 小鸡, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 6 Homolog (SUPT6H) (AA 71-120) antibodySUPT6H 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, 小鸡, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 6 Homolog (SUPT6H) (AA 532-666) antibodySUPT6H 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))
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别名
- SUPT6H
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背景
- Synonyms:KIAA0162, SPT6H Background:Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II(RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase(AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.
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分子量
- 230 kDa
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基因ID
- 9913
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UniProt
- Q7KZ85
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途径
- Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response
抗原
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