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- 抗原 See all Spt6 (SUPT6H) 抗体
- Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))
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抗原表位
- AA 1500-1726
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Spt6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
- 原理
- SUPT6H Rabbit pAb
- 序列
- IFPTVNGLFR WFKDHYQDPV PGITPSSSSR TRTPASINAT PANINLADLT RAVNALPQNM TSQMFSAIAA VTGQGQNPNA TPAQWASSQY GYGGSGGGSS AYHVFPTPAQ QPVATPLMTP SYSYTTPSQP ITTPQYHQLQ ASTTPQSAQA QPQPSSSSRQ RQQQPKSNSH AAIDWGKMAE QWLQEKEAER RKQKQRLTPR PSPSPMIEST PMSIAGDATP LLDEMDR
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1500-1726 of human SUPT6H (NP_003161.2).
- 亚型
- IgG
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anti-Suppressor of Ty 6 Homolog (SUPT6H) (N-Term) antibody
SUPT6H 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 豚鼠, 斑马鱼, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 6 Homolog (SUPT6H) antibodySUPT6H 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 6 Homolog (SUPT6H) (N-Term) antibodySUPT6H 适用: 人, 犬, 兔, Cow, 马, 豚鼠, 小鸡, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 6 Homolog (SUPT6H) (AA 71-120) antibodySUPT6H 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 豚鼠, 小鸡, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 6 Homolog (SUPT6H) (AA 532-666) antibodySUPT6H 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))
- 别名
- SUPT6H (SUPT6H 产品)
- 别名
- SPT6 antibody, SPT6H antibody, emb-5 antibody, 5131400N11Rik antibody, AI132449 antibody, Supt6h antibody, mKIAA0162 antibody, Spt6 antibody, wu:fj42h11 antibody, SUPT6H antibody, spt6 antibody, spt6h antibody, MGC146884 antibody, SPT6 homolog, histone chaperone antibody, suppressor of Ty 6 antibody, SUPT6H,-like protein to suppressor of ty 6 antibody, transcription elongation factor SPT6 antibody, suppressor of Ty 6 homolog (S. cerevisiae) antibody, chromatin-remodeling histone chaperone antibody, SUPT6H antibody, Supt6 antibody, Supt6h antibody, supt6h antibody, LOC100092175 antibody, SPT6 antibody
- 背景
- Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD of the RNAPII subunit RPB1 (POLR2A. The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10 as well as histone modifying enzymes (such as SETD2, to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.,SUPT6H,SPT6,SPT6H,emb-5,SPT6 homolog,Epigenetics & Nuclear Signaling,RNA Binding,Chromatin Remodeling,SUPT6H
- 分子量
- 61kDa/84kDa/199kDa
- 基因ID
- 6830
- UniProt
- Q7KZ85
- 途径
- Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response
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