SENP3 抗体
Quick Overview for SENP3 抗体 (ABIN7119591)
抗原
See all SENP3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SENP3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- SUMO1/sentrin/SMT3 specific peptidase 3
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))
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别名
- SENP3
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背景
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Synonyms: Sentrin-specific protease 3|SUMO-1-specific protease 3|Sentrin/SUMO-specific protease SENP3|SENP3|SSP3|SUSP3
Background: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP(5FMC) complex, the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
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分子量
- 65-70 kDa
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基因ID
- 26168
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UniProt
- Q9H4L4
抗原
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