SNX27 抗体
Quick Overview for SNX27 抗体 (ABIN7119360)
抗原
See all SNX27 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SNX27 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- sorting nexin family member 27
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亚型
- IgG
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anti-Sorting Nexin 27 (SNX27) (AA 458-497) antibody
SNX27 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 27 (SNX27) (C-Term) antibodySNX27 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SNX27 (Sorting Nexin 27 (SNX27))
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别名
- SNX27
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背景
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Synonyms: Sorting nexin-27|SNX27|KIAA0488
Background: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate(PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
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分子量
- 52-60 kDa
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基因ID
- 81609
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UniProt
- Q96L92
抗原
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