SETD2 抗体 (AA 2475-2564)
Quick Overview for SETD2 抗体 (AA 2475-2564) (ABIN7118991)
抗原
See all SETD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2475-2564
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原理
- SETD2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 2475-2564aa
Immunogen: SET domain containing 2
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亚型
- IgG
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anti-SET Domain Containing 2 (SETD2) (AA 803-1103) antibody
SETD2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Domain Containing 2 (SETD2) (AA 2054-2245) antibodySETD2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4G11E6 unconjugated
anti-SET Domain Containing 2 (SETD2) (N-Term) antibodySETD2 适用: 人, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Domain Containing 2 (SETD2) (N-Term) antibodySETD2 适用: 人, 小鼠, 大鼠, 犬, 马, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Domain Containing 2 (SETD2) antibodySETD2 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SET Domain Containing 2 (SETD2) (AA 21-50), (N-Term) antibodySETD2 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB2780 unconjugated
anti-SET Domain Containing 2 (SETD2) (AA 323-372) antibodySETD2 适用: 人, 小鼠, 大鼠, 犬, 马, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SETD2 (SET Domain Containing 2 (SETD2))
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别名
- SETD2
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背景
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Synonyms: Histone-lysine N-methyltransferase SETD2|HIF-1|Huntingtin yeast partner B|Huntingtin-interacting protein 1 (HIP-1)|Huntingtin-interacting protein B|Lysine N-methyltransferase 3A|Protein-lysine N-methyltransferase SETD2|SET domain-containing protein 2 (hSET2)|p231HBP|SETD2|HIF1|HYPB|KIAA1732|KMT3A|SET2
Background: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3(H3K36me3) using dimethylated 'Lys-36'(H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.
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分子量
- 287 kDa
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基因ID
- 29072
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UniProt
- Q9BYW2
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途径
- Tube Formation
抗原
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