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SATB1 抗体

SATB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7118794
发货至: 中国
  • 抗原 See all SATB1 抗体
    SATB1 (SATB Homeobox 1 (SATB1))
    适用
    • 53
    • 40
    • 23
    • 4
    • 4
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 47
    • 5
    • 1
    克隆类型
    • 39
    • 14
    多克隆
    标记
    • 25
    • 3
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    • 2
    • 2
    • 2
    • 2
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This SATB1 antibody is un-conjugated
    应用范围
    • 22
    • 19
    • 12
    • 12
    • 12
    • 11
    • 9
    • 8
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    SATB homeobox 1
    亚型
    IgG
    Top Product
    Discover our top product SATB1 Primary Antibody
  • 应用备注
    WB: 1:500-1:2000, IP: 1:200-1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    SATB1 (SATB Homeobox 1 (SATB1))
    别名
    SATB1 (SATB1 产品)
    背景
    Synonyms: Background:Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma(By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence(CSBS), at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions(MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes(e.g. PML at the MHC-I locus) and also by recruiting corepressors(HDACs) or coactivators(HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta-and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region(UR) of cytomegalovirus(CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA(interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
    分子量
    100 kDa
    基因ID
    6304
    UniProt
    Q01826
    途径
    Caspase Cascade in Apoptosis, Activated T Cell Proliferation
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