SATB1 抗体
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北京 101111
Quick Overview for SATB1 抗体 (ABIN7118794)
抗原
See all SATB1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SATB1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- SATB homeobox 1
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亚型
- IgG
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anti-SATB Homeobox 1 (SATB1) (AA 484-763) antibody
SATB1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (C-Term) antibodySATB1 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (AA 671-764) antibodySATB1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (pSer47) antibodySATB1 适用: 人, 小鼠 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (Internal Region) antibodyVerified SATB1 适用: 人 WB, IHC, IF, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (AA 1-763) antibodySATB1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) antibodySATB1 适用: 人 ICC, DB 宿主: 小鼠 Monoclonal 3548D4_2a unconjugated
anti-SATB Homeobox 1 (SATB1) antibodySATB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (AA 484-763) antibodySATB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (AA 611-660) antibodySATB1 适用: 人, 大鼠, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SATB1 (SATB Homeobox 1 (SATB1))
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别名
- SATB1
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背景
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Synonyms: DNA-binding protein SATB1|Special AT-rich sequence-binding protein 1|SATB1
Background: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma(By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence(CSBS), at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions(MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes(e.g. PML at the MHC-I locus) and also by recruiting corepressors(HDACs) or coactivators(HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta-and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region(UR) of cytomegalovirus(CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA(interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
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分子量
- 100 kDa
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基因ID
- 6304
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UniProt
- Q01826
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途径
- Caspase Cascade in Apoptosis, Activated T Cell Proliferation
抗原
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