RNF41 抗体
Quick Overview for RNF41 抗体 (ABIN7118659)
抗原
See all RNF41 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- RNF41 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ring finger protein 41
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亚型
- IgG
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anti-Ring Finger Protein 41 (RNF41) (AA 1-317) antibody
RNF41 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (Internal Region) antibodyRNF41 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 218-317) antibodyRNF41 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 218-317) antibodyRNF41 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C2 unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 1-317) antibodyRNF41 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 74-123) antibodyRNF41 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 255-281) antibodyRNF41 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- RNF41 (Ring Finger Protein 41 (RNF41))
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别名
- RNF41
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背景
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Synonyms: E3 ubiquitin-protein ligase NRDP1|RING finger protein 41|RING-type E3 ubiquitin transferase NRDP1|RNF41|FLRF|NRDP1
Background: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus(By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin(EPO) and interleukin-3(IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages(By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control(PubMed:24949970).
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分子量
- 36 kDa
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基因ID
- 10193
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UniProt
- Q9H4P4
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途径
- SARS-CoV-2 Protein Interactome
抗原
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