RNF41 抗体 (Internal Region)
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- 抗原 See all RNF41 抗体
- RNF41 (Ring Finger Protein 41 (RNF41))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RNF41 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- RNF41 Antibody detects endogenous levels of total RNF41.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human RNF41, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product RNF41 Primary Antibody
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anti-Ring Finger Protein 41 (RNF41) (AA 1-317) antibody
RNF41 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 218-317) antibodyRNF41 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 74-123) antibodyRNF41 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 斑马鱼, 马, 猴, Pig, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 1-317) antibodyRNF41 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 218-317) antibodyRNF41 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C2 unconjugated
anti-Ring Finger Protein 41 (RNF41) (AA 255-281) antibodyRNF41 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- RNF41 (Ring Finger Protein 41 (RNF41))
- 别名
- RNF41 (RNF41 产品)
- 别名
- FLRF antibody, NRDP1 antibody, 2210404G21Rik antibody, 4930511A05Rik antibody, 4933415P08Rik antibody, D10Ertd722e antibody, Nrdp1 antibody, wu:fi13f07 antibody, wu:fi25b06 antibody, zgc:55389 antibody, flrf antibody, ring finger protein 41 antibody, ring finger protein 41 S homeolog antibody, ring finger protein 41, E3 ubiquitin protein ligase antibody, RNF41 antibody, Rnf41 antibody, rnf41 antibody, rnf41.S antibody
- 背景
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Description: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).
Gene: RNF41
- 分子量
- 36 kDa
- 基因ID
- 10193
- UniProt
- Q9H4P4
- 途径
- SARS-CoV-2 Protein Interactome
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