RNF34 抗体
Quick Overview for RNF34 抗体 (ABIN7118654)
抗原
See all RNF34 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- RNF34 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ring finger protein 34
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亚型
- IgG
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anti-Ring Finger Protein 34 (RNF34) (AA 1-220) antibody
RNF34 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 34 (RNF34) (AA 1-373) antibodyRNF34 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 34 (RNF34) (AA 143-192) antibodyRNF34 适用: 人, Cow, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 34 (RNF34) (Middle Region) antibodyRNF34 适用: 人, Cow, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- RNF34 (Ring Finger Protein 34 (RNF34))
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别名
- RNF34
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背景
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Synonyms: E3 ubiquitin-protein ligase RNF34|Caspase regulator CARP1|Caspases-8 and -10-associated RING finger protein 1 (CARP-1)|FYVE-RING finger protein Momo|Human RING finger homologous to inhibitor of apoptosis protein (hRFI)|RING finger protein 34|RING finger protein RIFF|RING-type E3 ubiquitin transferase RNF34|RNF34
Background: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis(PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway(Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation(PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN(PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells(PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation(PubMed:25012219).
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基因ID
- 80196
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UniProt
- Q969K3
抗原
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