RNF20 抗体
Quick Overview for RNF20 抗体 (ABIN7118646)
抗原
See all RNF20 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- RNF20 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ring finger protein 20
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亚型
- IgG
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anti-Ring Finger Protein 20 (RNF20) (AA 1-975) antibody
RNF20 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (Internal Region) antibodyRNF20 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) antibodyRNF20 适用: 人 WB 宿主: 小鼠 Monoclonal 4C6 unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 177-276) antibodyRNF20 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 1-975) antibodyRNF20 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 177-276) antibodyRNF20 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E4 unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 576-625) antibodyRNF20 适用: 人, 小鼠, 犬, Cow, 豚鼠, Pig, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 108-157) antibodyRNF20 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 豚鼠, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (AA 1-260) antibodyRNF20 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 20 (RNF20) (N-Term) antibodyRNF20 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- RNF20 (Ring Finger Protein 20 (RNF20))
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别名
- RNF20
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背景
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Synonyms: E3 ubiquitin-protein ligase BRE1A (BRE1-A, hBRE1)|RING finger protein 20|RING-type E3 ubiquitin transferase BRE1A|RNF20|BRE1A
Background: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B(H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation(H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
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分子量
- 114 kDa
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基因ID
- 56254
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UniProt
- Q5VTR2
抗原
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