RFWD3 抗体
Quick Overview for RFWD3 抗体 (ABIN7118631)
抗原
See all RFWD3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- RFWD3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ring finger and WD repeat domain 3
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亚型
- IgG
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anti-Ring Finger and WD Repeat Domain 3 (RFWD3) (N-Term) antibody
RFWD3 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and WD Repeat Domain 3 (RFWD3) (Internal Region) antibodyRFWD3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and WD Repeat Domain 3 (RFWD3) (AA 651-749) antibodyRFWD3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6B4 unconjugated
anti-Ring Finger and WD Repeat Domain 3 (RFWD3) (Internal Region) antibodyRFWD3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))
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别名
- RFWD3
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背景
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Synonyms: E3 ubiquitin-protein ligase RFWD3|RING finger and WD repeat domain-containing protein 3|RING finger protein 201|RFWD3|RNF201
Background: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
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分子量
- 85 kDa
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基因ID
- 55159
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UniProt
- Q6PCD5
抗原
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