RNLS 抗体
Quick Overview for RNLS 抗体 (ABIN7118396)
抗原
See all RNLS 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- RNLS antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- chromosome 10 open reading frame 59
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亚型
- IgG1
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应用备注
- WB: 1:500-1:3000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))
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别名
- RNLS
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背景
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Synonyms: Renalase|Monoamine oxidase-C (MAO-C)|RNLS|C10orf59
Background: RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity.(PMID:15841207) This antibody is specific to RNLS.
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分子量
- 38 kDa
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基因ID
- 55328
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UniProt
- Q5VYX0
抗原
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