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RNLS 抗体

This 兔 多克隆 antibody specifically detects RNLS in WB, IHC, IP 和 ELISA. It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN7118395
发货至: 中国
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for RNLS 抗体 (ABIN7118395)

抗原

See all RNLS 抗体
RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

适用

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人, 小鼠, 大鼠

宿主

  • 59
  • 21
  • 1

克隆类型

  • 50
  • 31
多克隆

标记

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  • 1
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This RNLS antibody is un-conjugated

应用范围

  • 53
  • 32
  • 14
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  • 10
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Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA
  • 原理

    RNLS antibody

    纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    chromosome 10 open reading frame 59

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:5000, IHC: 1:20-1:200, IP: 1:200-1:2000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

    别名

    RNLS

    背景

    Synonyms: Renalase|Monoamine oxidase-C (MAO-C)|RNLS|C10orf59

    Background: RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity.(PMID:15841207) This antibody is specific to RNLS.

    分子量

    35 kDa

    基因ID

    55328

    UniProt

    Q5VYX0
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