RACGAP1 抗体 (AA 400-632)
Quick Overview for RACGAP1 抗体 (AA 400-632) (ABIN7118247)
抗原
See all RACGAP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 400-632
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原理
- RACGAP1 antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 400-632aa
Immunogen: Rac GTPase activating protein 1
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亚型
- IgG1
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应用备注
- WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:20-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- RACGAP1 (Rac GTPase Activating Protein 1 (RACGAP1))
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别名
- RACGAP1
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背景
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Synonyms: Rac GTPase-activating protein 1|Male germ cell RacGap (MgcRacGAP)|Protein CYK4 homolog (CYK4, HsCYK-4)|RACGAP1|KIAA1478|MGCRACGAP
Background: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP(GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.
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分子量
- 71 kDa
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基因ID
- 29127
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UniProt
- Q9H0H5
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途径
- Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling of Hepatocyte Growth Factor Receptor
抗原
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