电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

POFUT1 抗体

This anti-POFUT1 antibody is a 兔 多克隆 antibody detecting POFUT1 in WB, IHC, ELISA, IP 和 IF. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7117981
发货至: 中国

Quick Overview for POFUT1 抗体 (ABIN7117981)

抗原

See all POFUT1 抗体
POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))

适用

  • 39
  • 11
  • 7
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 39
  • 2

克隆类型

  • 38
  • 2
多克隆

标记

  • 31
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
This POFUT1 antibody is un-conjugated

应用范围

  • 32
  • 24
  • 17
  • 9
  • 8
  • 7
  • 6
  • 5
  • 4
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    protein O-fucosyltransferase 1

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))

    别名

    POFUT1

    背景

    Synonyms:FUT12, KIAA0180 Background:Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors(AChRs).

    分子量

    44 kDa

    基因ID

    23509

    UniProt

    Q9H488

    途径

    Notch Signaling, SARS-CoV-2 Protein Interactome
You are here:
Chat with us!