电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

POFUT1 抗体

POFUT1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7117981
发货至: 中国
  • 抗原 See all POFUT1 抗体
    POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))
    适用
    • 32
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 31
    • 2
    克隆类型
    • 31
    • 2
    多克隆
    标记
    • 23
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This POFUT1 antibody is un-conjugated
    应用范围
    • 26
    • 20
    • 15
    • 9
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    protein O-fucosyltransferase 1
    亚型
    IgG
    Top Product
    Discover our top product POFUT1 Primary Antibody
  • 应用备注
    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))
    别名
    POFUT1 (POFUT1 产品)
    背景
    Synonyms:FUT12, KIAA0180 Background:Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors(AChRs).
    分子量
    44 kDa
    基因ID
    23509
    UniProt
    Q9H488
    途径
    Notch Signaling, SARS-CoV-2 Protein Interactome
You are here:
Chat with us!