PQBP1 抗体
Quick Overview for PQBP1 抗体 (ABIN7117652)
抗原
See all PQBP1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- PQBP1 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- polyglutamine binding protein 1
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- PQBP1 (Polyglutamine Binding Protein 1 (PQBP1))
-
别名
- PQBP1
-
背景
-
Synonyms: Polyglutamine-binding protein 1 (PQBP-1)|38 kDa nuclear protein containing a WW domain (Npw38)|Polyglutamine tract-binding protein 1|PQBP1|NPW38
Background: Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species(PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.
-
分子量
- 38 kDa, 30 kDa
-
基因ID
- 10084
-
UniProt
- O60828
-
途径
- Ribonucleoprotein Complex Subunit Organization
抗原
-