PARP3 抗体
Quick Overview for PARP3 抗体 (ABIN7117630)
抗原
See all PARP3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PARP3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- poly(ADP-ribose) polymerase family, member 3
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))
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别名
- PARP3
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背景
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Synonyms: Protein mono-ADP-ribosyltransferase PARP3|ADP-ribosyltransferase diphtheria toxin-like 3 (ARTD3)|DNA ADP-ribosyltransferase PARP3|IRT1|NAD(+) ADP-ribosyltransferase 3 (ADPRT-3)|Poly [ADP-ribose] polymerase 3 (PARP-3, hPARP-3)|Poly[ADP-ribose] synthase 3 (pADPRT-3)|PARP3|ADPRT3|ADPRTL3
Background: Involved in the base excision repair(BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
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分子量
- 60-62 kDa
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基因ID
- 10039
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UniProt
- Q9Y6F1
抗原
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