PLK2 抗体
Quick Overview for PLK2 抗体 (ABIN7117618)
抗原
See all PLK2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PLK2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- polo-like kinase 2(Drosophila)
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亚型
- IgG
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anti-Polo-Like Kinase 2 (PLK2) (AA 322-671) antibody
PLK2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 666-685), (C-Term) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 375-406), (C-Term) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB0873 unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 585-685) antibodyPLK2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (Internal Region) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 1268-1341) antibodyPLK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 336-685) antibodyPLK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (Internal Region) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 261-310) antibodyPLK2 适用: 人, 小鼠, 大鼠, 豚鼠, 马, Cow, 犬, 兔, 斑马鱼, Bat, 小鸡, Hamster, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 354-382) antibodyPLK2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB34683 unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PLK2 (Polo-Like Kinase 2 (PLK2))
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别名
- PLK2
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背景
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Synonyms: Serine/threonine-protein kinase PLK2|Polo-like kinase 2 (PLK-2, hPlk2)|Serine/threonine-protein kinase SNK (hSNK)|Serum-inducible kinase|PLK2|SNK
Background: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
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分子量
- 75-80 kDa
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UniProt
- Q9NYY3
抗原
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