PHAX 抗体
Quick Overview for PHAX 抗体 (ABIN7117517)
抗原
See all PHAX 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PHAX antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- phosphorylated adaptor for RNA export
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亚型
- IgG
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anti-phosphorylated Adaptor For RNA Export (PHAX) (AA 6-243) antibody
PHAX 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphorylated Adaptor For RNA Export (PHAX) (AA 297-326), (C-Term) antibodyPHAX 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32550 unconjugated
anti-phosphorylated Adaptor For RNA Export (PHAX) (AA 304-334), (C-Term) antibodyPHAX 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PHAX (phosphorylated Adaptor For RNA Export (PHAX))
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别名
- PHAX
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背景
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Synonyms: Phosphorylated adapter RNA export protein|RNA U small nuclear RNA export adapter protein|PHAX|RNUXA
Background: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex(CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs(snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner(By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA(snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated(TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
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分子量
- 55 kDa
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基因ID
- 51808
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UniProt
- Q9H814
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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