PAN2 抗体
Quick Overview for PAN2 抗体 (ABIN7117214)
抗原
See all PAN2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PAN2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- PAN2 poly(A) specific ribonuclease subunit homolog
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亚型
- IgG
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anti-PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2) (AA 628-908) antibody
PAN2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2) (AA 1099-1198) antibodyPAN2 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 6A7 unconjugated
anti-PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2) (AA 700-1000) antibodyPAN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))
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别名
- PAN2
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背景
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Synonyms: PAN2-PAN3 deadenylation complex catalytic subunit PAN2|Inactive ubiquitin carboxyl-terminal hydrolase 52|PAB1P-dependent poly(A)-specific ribonuclease|Poly(A)-nuclease deadenylation complex subunit 2 (PAN deadenylation complex subunit 2)|PAN2|KIAA0710|USP52
Background: Catalytic subunit of the poly(A)-nuclease(PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein(PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
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分子量
- 127 kDa
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基因ID
- 9924
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UniProt
- Q504Q3
抗原
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