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OTUD7B 抗体

This anti-OTUD7B antibody is a 兔 多克隆 antibody detecting OTUD7B in ELISA, WB, IHC 和 IP. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7117156
发货至: 中国

Quick Overview for OTUD7B 抗体 (ABIN7117156)

抗原

See all OTUD7B 抗体
OTUD7B (OTU Domain Containing 7B (OTUD7B))

适用

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人, 小鼠, 大鼠

宿主

  • 31
  • 4

克隆类型

  • 33
  • 2
多克隆

标记

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This OTUD7B antibody is un-conjugated

应用范围

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ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    OTU domain containing 7B

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    OTUD7B (OTU Domain Containing 7B (OTUD7B))

    别名

    OTUD7B

    背景

    Synonyms:ZA20D1 Background:Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains, however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

    分子量

    100 kDa

    基因ID

    56957

    UniProt

    Q6GQQ9
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