OTUD7B 抗体 (C-Term)
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- 抗原 See all OTUD7B 抗体
- OTUD7B (OTU Domain Containing 7B (OTUD7B))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This OTUD7B antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- OTUD7B Antibody detects endogenous levels of total OTUD7B.
- 预测反应
- Pig,Bovine,Sheep,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human OTUD7B, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product OTUD7B Primary Antibody
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anti-OTU Domain Containing 7B (OTUD7B) (AA 759-858) antibody
OTUD7B 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2B4 unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 235-347) antibodyOTUD7B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 530-700) antibodyOTUD7B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (Middle Region) antibodyOTUD7B 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 1-427) antibodyOTUD7B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 559-608) antibodyOTUD7B 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 612-661) antibodyOTUD7B 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, Pig, 兔, Bat, 猴, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 757-784), (C-Term) antibodyOTUD7B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- OTUD7B (OTU Domain Containing 7B (OTUD7B))
- 别名
- OTUD7B (OTUD7B 产品)
- 别名
- OTUD7B antibody, ZA20D1 antibody, za20d1 antibody, zgc:152772 antibody, cezanne antibody, CEZANNE antibody, 2900060B22Rik antibody, 4930463P07Rik antibody, AI462125 antibody, Trabid2 antibody, Za20d1 antibody, RGD1308111 antibody, OTU deubiquitinase 7B antibody, OTU domain containing 7B antibody, OTUD7B antibody, otud7b antibody, Otud7b antibody
- 背景
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Description: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro), however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.
Gene: OTUD7B
- 分子量
- 100 kDa
- 基因ID
- 56957
- UniProt
- Q6GQQ9
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