NEUROD1 抗体
Quick Overview for NEUROD1 抗体 (ABIN7116829)
抗原
See all NEUROD1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- NEUROD1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- neurogenic differentiation 1
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- NEUROD1 (Neuronal Differentiation 1 (NEUROD1))
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别名
- NEUROD1
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背景
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Synonyms: Neurogenic differentiation factor 1 (NeuroD, NeuroD1)|Class A basic helix-loop-helix protein 3 (bHLHa3)|NEUROD1|BHLHA3|NEUROD
Background: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis(By similarity).
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分子量
- 50 kDa
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基因ID
- 4760
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UniProt
- Q13562
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途径
- Dopaminergic Neurogenesis, Hormone Transport, Carbohydrate Homeostasis
抗原
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