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METAP2 抗体

The 兔 多克隆 anti-METAP2 antibody is suitable to detect METAP2 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, ELISA 和 IHC.
产品编号 ABIN7116239
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for METAP2 抗体 (ABIN7116239)

抗原

See all METAP2 抗体
METAP2 (Methionyl Aminopeptidase 2 (METAP2))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This METAP2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 原理

    METAP2 antibody

    纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    methionyl aminopeptidase 2

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IHC: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    METAP2 (Methionyl Aminopeptidase 2 (METAP2))

    别名

    METAP2

    背景

    Synonyms: Methionine aminopeptidase 2 (MAP 2, MetAP 2)|Initiation factor 2-associated 67 kDa glycoprotein (p67, p67eIF2)|Peptidase M|METAP2|MNPEP|P67EIF2

    Background: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged(Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

    分子量

    67 kDa

    基因ID

    10988

    UniProt

    P50579

    途径

    Regulation of G-Protein Coupled Receptor Protein Signaling
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