MCTS1 抗体
Quick Overview for MCTS1 抗体 (ABIN7116036)
抗原
See all MCTS1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- MCTS1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- malignant T cell amplified sequence 1
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亚型
- IgG
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anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibody
MCTS1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) antibodyMCTS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (N-Term) antibodyVerified MCTS1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G1-2A2 unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (N-Term) antibodyMCTS1 适用: 人, 大鼠, Cow, 犬, 豚鼠, 斑马鱼, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-30), (N-Term) antibodyMCTS1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB20015 unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
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别名
- MCTS1
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背景
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Synonyms: Malignant T-cell-amplified sequence 1 (MCT-1)|Multiple copies T-cell malignancies|MCTS1|MCT1
Background: Anti-oncogene that plays a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation, promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer, recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation, promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
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分子量
- 21 kDa
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基因ID
- 28985
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UniProt
- Q9ULC4
抗原
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