LGR4 抗体
Quick Overview for LGR4 抗体 (ABIN7115829)
抗原
See all LGR4 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- LGR4 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- leucine-rich repeat-containing G protein-coupled receptor 4
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亚型
- IgG
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anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) antibody
LGR4 适用: 人 FACS, cELISA 宿主: 大鼠 Monoclonal BBX-1H1 unconjugated
anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) (AA 234-365) antibodyLGR4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) (C-Term) antibodyLGR4 适用: 人, 猴, 兔, Pig, Cow, 犬, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) (C-Term) antibodyLGR4 适用: 人, 猴, 兔, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) (Cytoplasmic Domain) antibodyLGR4 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) (AA 852-950) antibodyLGR4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 8F6 unconjugated
anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) (AA 320-540) antibodyLGR4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) (N-Term) antibodyLGR4 适用: 人, 小鼠, 大鼠, 猴, 兔, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) (C-Term) antibodyLGR4 适用: 人, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) antibodyLGR4 适用: 人, 小鼠 FACS, cELISA 宿主: 大鼠 Monoclonal BBX-3A8 unconjugated
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应用备注
- IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- LGR4 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4))
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别名
- LGR4
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背景
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Synonyms: Leucine-rich repeat-containing G-protein coupled receptor 4|G-protein coupled receptor 48|LGR4|GPR48
Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin(NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development, required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP(By similarity).
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基因ID
- 55366
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UniProt
- Q9BXB1
抗原
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