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KISS1 抗体 (AA 124-138)

This anti-KISS1 antibody is a 兔 多克隆 antibody detecting KISS1 in WB, IHC, ELISA 和 IF. Suitable for 人 和 小鼠.
产品编号 ABIN7115721
发货至: 中国

Quick Overview for KISS1 抗体 (AA 124-138) (ABIN7115721)

抗原

See all KISS1 抗体
KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

适用

  • 34
  • 15
  • 5
人, 小鼠

宿主

  • 33
  • 6

克隆类型

  • 34
  • 5
多克隆

标记

  • 28
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This KISS1 antibody is un-conjugated

应用范围

  • 22
  • 13
  • 12
  • 7
  • 7
  • 4
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
  • 抗原表位

    • 8
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 124-138

    原理

    KISS1 antibody

    纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    Immunogen sequence: A synthetic peptide,124-138aa

    Immunogen: KiSS-1 metastasis-suppressor

    亚型

    IgG
  • 应用备注

    WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

    别名

    KISS1

    背景

    Synonyms: Metastasis-suppressor KiSS-1|Kisspeptin-1|Metastin Alternative names: Kisspeptin-54|Kisspeptin-14|Kisspeptin-13|Kisspeptin-10|KISS1

    Background: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

    分子量

    16-20 kDa

    基因ID

    3814

    UniProt

    Q15726

    途径

    Positive Regulation of Peptide Hormone Secretion
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