IWS1 抗体
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北京 101111
Quick Overview for IWS1 抗体 (ABIN7115537)
抗原
适用
宿主
克隆类型
标记
应用范围
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原理
- IWS1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- IWS1 homolog
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亚型
- IgG
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anti-IWS1 Homolog (IWS1) (AA 570-819) antibody
IWS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IWS1 Homolog (IWS1) (N-Term) antibodyIWS1 适用: 人, 大鼠, 小鼠, Cow, 犬, 山羊, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-IWS1 Homolog (IWS1) antibodyIWS1 适用: 人 WB, ELISA, IHC 宿主: 兔 unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- IWS1 (IWS1 Homolog (IWS1))
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别名
- IWS1
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背景
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Synonyms: Protein IWS1 homolog|IWS1-like protein|IWS1|IWS1L
Background: Transcription factor which plays a key role in defining the composition of the RNA polymerase II(RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
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分子量
- 116-120 kDa
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基因ID
- 55677
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UniProt
- Q96ST2
抗原
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