Inversin 抗体
Quick Overview for Inversin 抗体 (ABIN7115502)
抗原
See all Inversin (INVS) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- INVS antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- inversin
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亚型
- IgG
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anti-Inversin (INVS) (AA 1-101) antibody
INVS 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Inversin (INVS) (AA 1-237) antibodyINVS 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inversin (INVS) (AA 1-91) antibodyINVS 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Inversin (INVS) (AA 1-90) antibodyINVS 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- Inversin (INVS)
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别名
- INVS
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背景
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Synonyms: Inversin|Inversion of embryo turning homolog|Nephrocystin-2|INVS|INV|NPHP2
Background: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled(DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8(By similarity). Does not seem to be strictly required for ciliogenesis(By similarity).
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分子量
- 110-115 kDa
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基因ID
- 27130
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UniProt
- Q9Y283
抗原
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