ING4 抗体
Quick Overview for ING4 抗体 (ABIN7115237)
抗原
See all ING4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- ING4 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- inhibitor of growth family, member 4
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200, IP: 1:200-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- ING4 (Inhibitor of Growth Family, Member 4 (ING4))
-
别名
- ING4
-
背景
-
Synonyms: Inhibitor of growth protein 4|p29ING4|ING4
Background: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's(HIF) activity by interacting with HIF prolyl hydroxylase 2(EGLN1). Can enhance aopotosis induced by serum starvation in mammary epithelial cell line HC11(By similarity).
-
分子量
- 29 kDa
-
基因ID
- 51147
-
UniProt
- Q9UNL4
抗原
-