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ING4 抗体 (C-Term)

ING4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB47839 unconjugated
产品编号 ABIN1944775
发货至: 中国
  • 抗原 See all ING4 抗体
    ING4 (Inhibitor of Growth Family, Member 4 (ING4))
    抗原表位
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 162-195, C-Term
    适用
    • 29
    • 16
    • 13
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 25
    • 3
    • 1
    克隆类型
    • 28
    • 1
    多克隆
    标记
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ING4 antibody is un-conjugated
    应用范围
    • 17
    • 13
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    B, C, M
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.
    克隆位点
    RB47839
    亚型
    Ig Fraction
    Top Product
    Discover our top product ING4 Primary Antibody
  • 应用备注
    WB: 1:1000. IHC-P: 1:25
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Raho, Miranda, Tamborini, Pierotti, Greco: "Detection of novel mRNA splice variants of human ING4 tumor suppressor gene." in: Oncogene, Vol. 26, Issue 36, pp. 5247-57, (2007) (PubMed).

    Shiseki, Nagashima, Pedeux, Kitahama-Shiseki, Miura, Okamura, Onogi, Higashimoto, Appella, Yokota, Harris: "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity." in: Cancer research, Vol. 63, Issue 10, pp. 2373-8, (2003) (PubMed).

  • 抗原
    ING4 (Inhibitor of Growth Family, Member 4 (ING4))
    别名
    ING4 (ING4 产品)
    别名
    wu:fb11d09 antibody, wu:fb50e02 antibody, zgc:110619 antibody, ING4 antibody, my036 antibody, p29ING4 antibody, D6Wsu147e antibody, D6Xrf92 antibody, inhibitor of growth family, member 4 antibody, inhibitor of growth family member 4 antibody, ing4 antibody, ING4 antibody, Ing4 antibody
    背景
    Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
    分子量
    28530
    基因ID
    51147
    UniProt
    Q9UNL4
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