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IKZF1 抗体

This anti-IKZF1 antibody is a 兔 多克隆 antibody detecting IKZF1 in WB, ELISA, IHC 和 IP. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7115178
发货至: 中国

Quick Overview for IKZF1 抗体 (ABIN7115178)

抗原

See all IKZF1 抗体
IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

适用

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人, 小鼠, 大鼠

宿主

  • 57
  • 11
  • 2

克隆类型

  • 56
  • 14
多克隆

标记

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This IKZF1 antibody is un-conjugated

应用范围

  • 55
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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • 原理

    IKZF1 antibody

    纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    IKAROS family zinc finger 1(Ikaros)

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

    别名

    IKZF1

    背景

    Synonyms: DNA-binding protein Ikaros|Ikaros family zinc finger protein 1|Lymphoid transcription factor LyF-1|IKZF1|IK1|IKAROS|LYF1|ZNFN1A1

    Background: Transcription regulator of hematopoietic cell differentiation(PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B-and T-cells. Binds and activates the enhancer(delta-A element) of the CD3-delta gene. Repressor of the TDT(fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF(SWI/SNF), in a single complex(PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells(RPCs)(By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms(PubMed:17135265, PubMed:17934067).

    分子量

    57-70 kDa

    基因ID

    10320

    UniProt

    Q13422

    途径

    Production of Molecular Mediator of Immune Response
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