IKZF1 抗体
Quick Overview for IKZF1 抗体 (ABIN7115178)
抗原
See all IKZF1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- IKZF1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- IKAROS family zinc finger 1(Ikaros)
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
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别名
- IKZF1
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背景
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Synonyms: DNA-binding protein Ikaros|Ikaros family zinc finger protein 1|Lymphoid transcription factor LyF-1|IKZF1|IK1|IKAROS|LYF1|ZNFN1A1
Background: Transcription regulator of hematopoietic cell differentiation(PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B-and T-cells. Binds and activates the enhancer(delta-A element) of the CD3-delta gene. Repressor of the TDT(fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF(SWI/SNF), in a single complex(PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells(RPCs)(By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms(PubMed:17135265, PubMed:17934067).
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分子量
- 57-70 kDa
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基因ID
- 10320
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UniProt
- Q13422
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途径
- Production of Molecular Mediator of Immune Response
抗原
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