HUS1 抗体
Quick Overview for HUS1 抗体 (ABIN7115125)
抗原
See all HUS1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- HUS1 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- HUS1 checkpoint homolog (S. pombe)
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
-
别名
- HUS1
-
背景
-
Synonyms: Checkpoint protein HUS1 (hHUS1)|HUS1
Background: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
-
分子量
- 32 kDa
-
基因ID
- 3364
-
UniProt
- O60921
抗原
-