HMHA1 抗体
Quick Overview for HMHA1 抗体 (ABIN7115031)
抗原
See all HMHA1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- histocompatibility(minor) HA-1
-
亚型
- IgG
-
-
anti-Histocompatibility (Minor) HA-1 (HMHA1) (AA 91-190) antibody
HMHA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H7 unconjugated
anti-Histocompatibility (Minor) HA-1 (HMHA1) (AA 877-903) antibodyHMHA1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21759 unconjugated
anti-Histocompatibility (Minor) HA-1 (HMHA1) antibodyHMHA1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Histocompatibility (Minor) HA-1 (HMHA1) (AA 57-71) antibodyVerified HMHA1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
-
-
应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
-
有效期
- 12 months
-
-
- HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))
-
别名
- HMHA1
-
背景
- Synonyms:KIAA0223 Background:GTPase activator for the Rho-type GTPases. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens(mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease(GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation(BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte(CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
-
分子量
- 140-150kd
-
基因ID
- 23526
-
UniProt
- Q92619
抗原
-
