PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
-20°C for 12 months (Avoid repeated freeze / thaw cycles.)
有效期
12 months
抗原
HNRNPK
(Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))
别名
HNRNPK
背景
Synonyms:CSBP, hnRNP K, HNRNPK, HNRPK, TUNP Background:One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction(By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21(lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.