HGS 抗体
Quick Overview for HGS 抗体 (ABIN7114957)
抗原
See all HGS 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- HGS antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- hepatocyte growth factor-regulated tyrosine kinase substrate
-
亚型
- IgG
-
-
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 513-612) antibody
HGS 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 6D11 unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (C-Term) antibodyHGS 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (Internal Region) antibodyHGS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (Internal Region) antibodyHGS 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) antibodyHGS 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 513-612) antibodyHGS 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 451-500) antibodyHGS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 301-350) antibodyHGS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 548-777) antibodyHGS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) antibodyHGS 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 3H7 unconjugated
-
-
应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
-
别名
- HGS
-
背景
-
Synonyms: Hepatocyte growth factor-regulated tyrosine kinase substrate|Hrs|Protein pp110|HGS|HRS
Background: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body(MVBs) when complexed with STAM(ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
-
分子量
- 110-115 kDa
-
基因ID
- 9146
-
UniProt
- O14964
-
途径
- EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation
抗原
-
