BHLHb31 antibody, CHF2 antibody, HERP2 antibody, HESR1 antibody, HRT-1 antibody, OAF1 antibody, AI316788 antibody, AI414254 antibody, HRT1 antibody, Herp2 antibody, Hesr1 antibody, bHLHb31 antibody, hesr-1 antibody, id:ibd1292 antibody, zgc:110572 antibody, bc8 antibody, chf2 antibody, herp2 antibody, hesr1 antibody, hrt1 antibody, oaf1 antibody, xbc8 antibody, hes related family bHLH transcription factor with YRPW motif 1 antibody, hairy/enhancer-of-split related with YRPW motif 1 antibody, hes-related family bHLH transcription factor with YRPW motif 1 antibody, hes related family bHLH transcription factor with YRPW motif 1 S homeolog antibody, HEY1 antibody, Hey1 antibody, hey1 antibody, hey1.S antibody
背景
Synonyms:BHLHB31, CHF2, HERP2, HESR1, HRT1 Background:Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).