FBXW5 抗体
Quick Overview for FBXW5 抗体 (ABIN7114041)
抗原
See all FBXW5 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- FBXW5 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- F-box and WD repeat domain containing 5
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亚型
- IgG
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anti-F-Box and WD Repeat Domain Containing 5 (FBXW5) (AA 265-494) antibody
FBXW5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 5 (FBXW5) (AA 324-350) antibodyFBXW5 适用: 人 WB 宿主: 兔 Polyclonal RB40653 unconjugated
anti-F-Box and WD Repeat Domain Containing 5 (FBXW5) (AA 184-566) antibodyFBXW5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 5 (FBXW5) (AA 1-159) antibodyFBXW5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
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别名
- FBXW5
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背景
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Synonyms: F-box/WD repeat-containing protein 5|F-box and WD-40 domain-containing protein 5|FBXW5|FBW5
Background: Substrate recognition component of both SCF(SKP1-CUL1-F-box protein) and DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B(IL1B) signaling pathway.
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分子量
- 65 kDa
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基因ID
- 54461
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UniProt
- Q969U6
抗原
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