ERCC6 抗体
Quick Overview for ERCC6 抗体 (ABIN7113989)
抗原
See all ERCC6 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ERCC6 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- excision repair cross-complementing rodent repair deficiency, complementation group 6
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))
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别名
- ERCC6
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背景
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Synonyms: DNA excision repair protein ERCC-6|ATP-dependent helicase ERCC6|Cockayne syndrome protein CSB|ERCC6|CSB
Background: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex(DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.
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分子量
- 150 kDa
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基因ID
- 2074
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UniProt
- Q03468
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途径
- DNA Damage Repair, Chromatin Binding
抗原
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